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OSPS Version 11 → PBPK-QSP Modeling with MoBi®

Dermal Absorption of Caffeine (M05-11)


Description
Caffeine is the most widely consumed psychoactive or central nervous system (CNS) stimulant in the world. In this course, its dermal application on the chest will be investigated and the impact of hair in absorption is shown.
Content
  • Info: Caffeine
  • Info: The Structure of the Skin Permeation Model
  • Dermal PBPK Model in MoBi®
  • Skin Permeation Model
  • Molecules: Rename Permeant
  • Info: Chest Skin
  • Spatial Structure: Skin Layer Thickness
  • Spatial Structure: Set Caffeine Characteristics
  • Spatial Structure: Set Caffeine Application
  • Catch-Up Point 1
  • Events: Multiple Dosing
  • Parameter Start Values
  • Simulation: Skin Module
  • Export PKML Files from MoBi
  • Catch-Up Point 2
  • Base PBPK Model in PK-Sim®
  • Caffeine Model
  • Export From PK-Sim to MoBi
  • Catch-Up Point 3
  • Combine Base and Dermal PBPK Model in MoBi®
  • Spatial Structures: Merge
  • Simulations: Merge
  • Catch-Up Point 4
  • Simulation Settings
  • Molecular Start Values
  • Observed Data
  • Simulation: Turn into Combined Model
  • Simulation: Run Combined Model
  • Final Overview
  • The End
  • Brief Course Evaluation
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
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