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OSPS Version 11 → PBPK-QSP Modeling with MoBi®

Formula Types (M07-11)


Description
You will learn to apply different equation types (Explicit, Sum, Conditional). We will exemplarily assume a simplified circadian clearance of the antiviral medication aciclovir.
Content
  • Introduction
  • Info: Equations in the OSPS
  • Start with the Aciclovir PBPK Model
  • Building Blocks
  • Spatial Structure: Parameter of Circadian Rhythm
  • Passive Transporter: Daytime-Dependent Renal Clearance
  • Catch-Up Point 1
  • Molecules: Total Amount of Aciclovir
  • Spatial Structure: Plasma to Blood Cell Ratio of Aciclovir
  • Catch-Up Point 2
  • Simulations
  • Simulation: With Circadian Clearance
  • Simulation: Without Circadian Clearance
  • Final Overview
  • The End
  • Brief Course Evaluation
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
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