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OSPS Version 11 → Using R-Packages

In Vitro In Vivo Correlation (IVIVC) (01-11)


Description
This course explores 2 approaches to establish an IVIVC between in vitro dissolution and in vivo fraction dissolved to predict PK exposure of formulations.
Content
  • Introduction
  • Info: In Vitro In Vivo Correlation (IVIVC)
  • Weibull IVIVC Project
  • PK-SIM Project - Weibull IVIVC
  • Add Formulations
  • Add Administration Protocols
  • Add Observed data
  • Catch-up point 1.1.
  • Create Solution Simulation
  • Run Solution Simulation
  • Create Parameter Identification - Solution
  • Run Parameter Identification - Solution
  • Catch-up point 1.2.
  • Clone Solution Simulation
  • Create Parameter Identification - Tablets
  • Run Parameter Identification - Tablets
  • Catch-up point 1.3.
  • Establish the correlation
  • Calculate the predictability of the IVIVC
  • Final Overview
  • Scaling factors IVIVC Project
  • PK-SIM Project - Scaling Factors IVIVC
  • Add formulations
  • Create Tablet Simulations
  • Catch-up point 2.1.
  • Send Simulations to MoBi
  • Add Scaling Factors
  • Catch-up point 2.2.
  • Modify dissolution equations
  • Check Implementation
  • Catch-up point 2.3.
  • Clone Event Building Block
  • Add Observed Data
  • Catch-up point 2.4.
  • Create Simulations
  • Create and Run Parameter Identification
  • Catch-up point 2.5.
  • Estimate scaling factors using NPOD
  • Final Overview
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
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