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New: OSPS Version 12 → PBPK-QSP Modeling with MoBi®

Observer (M03-12)


Description
In this exercise, you will learn how to create different types of observers and export them to PK-Sim® using a simulation of omeprazole as an example.
Content
  • Info: Observer
  • PK-Sim®
  • Download the Moclobemide-Omeprazole-DDI Scenario
  • Target expression
  • MoBi®
  • Molecule Observer
  • Container Observer
  • Simulate in MoBi®
  • Catch-Up Point 1
  • Observer for the target occupancy with two competing ligands
  • Observer for the total target occupancy
  • Observer for individual target occupancy of the two competing ligands
  • Simulation with the new target occupancy
  • Export Observer as PKML
  • PK-Sim®
  • Load Observers into PK-Sim®
  • Simulation
  • The End
  • Final Overview
  • Learning Outcome
  • Brief Course Evaluation
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
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