Course
In Vitro In Vivo Correlation (IVIVC) (01-11)
Outgoing: OSPS Version 11
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Using R-Packages
In Vitro In Vivo Correlation (IVIVC) (01-11)
This course explores 2 approaches to establish an IVIVC between in vitro dissolution and in vivo fraction dissolved to predict PK exposure of formulations.
In Vitro In Vivo Correlation (IVIVC) (01-12)
New: OSPS Version 12
/
Using R-Packages
In Vitro In Vivo Correlation (IVIVC) (01-12)
This course explores 2 approaches to establish an IVIVC between in vitro dissolution and in vivo fraction dissolved to predict PK exposure of formulations.
Starting with the OSP Suite (I01-12)
New: OSPS Version 12
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An Introduction
Starting with the OSP Suite (I01-12)
To get you started, we will explain to you general concepts and the various tools of the Open Systems Pharmacology Suite (OSPS). We will also give a visual impression of what PBPK modeling is and explain who we are.
Protein Expression & Function (I02-12)
New: OSPS Version 12
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An Introduction
Protein Expression & Function (I02-12)
This course provides information about the OSPS expression database and how to install it.
Model Qualifications and Reports (I03-12)
New: OSPS Version 12
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An Introduction
Model Qualifications and Reports (I03-12)
Import, Reporting, Export - an order that ensures you can work across platforms and keep others in the loop.
A Two Container Model (M01-12)
New: OSPS Version 12
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PBPK-QSP Modeling with MoBi®
A Two Container Model (M01-12)
In this course, you will start a new MoBi project from scratch. You will create two physical containers connected by a neighborhood. In those containers, two molecules will be transferred from one container to the other. You will also learn how...
Formula Types (M02-12)
New: OSPS Version 12
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PBPK-QSP Modeling with MoBi®
Formula Types (M02-12)
You will learn to apply different equation types (Explicit, Sum, Conditional). We will exemplarily assume a simplified circadian clearance of the antiviral medication aciclovir.
Observer (M03-12)
New: OSPS Version 12
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PBPK-QSP Modeling with MoBi®
Observer (M03-12)
In this exercise, you will learn how to create different types of observers and export them to PK-Sim® using a simulation of omeprazole as an example.
Lysosomal Trapping (M04-12)
New: OSPS Version 12
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PBPK-QSP Modeling with MoBi®
Lysosomal Trapping (M04-12)
In this exercise, you will learn how to extend a PBPK model by new compartments and model the distribution of compounds based on partition coefficients. You will implement a simplified model of lysosomal trapping. Lysosomes are organelles within...
Female Reproductive Tract (M05-12)
New: OSPS Version 12
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PBPK-QSP Modeling with MoBi®
Female Reproductive Tract (M05-12)
This course aims to learn how to extend a physiologically-based pharmacokinetic (PBPK) model with the female reproductive tract extension module.

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