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New: OSPS Version 12 → 3 MoBi®

Large Molecule PBPK & TMDD (M07-12)


Description
In this course you will learn how to set up a simulation for large molecules (proteins and peptides) in PK-Sim, export it to MoBi, and implement a Target-Mediated Drug Disposition (TMDD) model. This is demonstrated in the context of a model for antibody-drug conjugate PK and PD.
The course is the first in a series of three. In the next courses "Adding an Organ (Tumor)" (M08-12) and "QSP: Tumor Growth Inhibition" (M09-12), you will also learn how to generate a tumor compartment and link its volume to a tumor growth model.
Content
  • Info: Course Goal
  • Info: Background on Large Molecule PBPK Model
  • ADC: Antibody-drug conjugate PK in PK-Sim®
  • Info: Antibody Drug Conjugate (ADC)
  • Expression Profile: TMEFF2
  • Individual: Mouse
  • Compound: ADC
  • Administration Protocol: Intravenous Bolus
  • Catch-Up Point 1
  • Simulation: 0.3 mg/kg ADC
  • Observed Data: ADC
  • Catch-Up Point 2
  • nAb & tox: Naked Antibody and Toxophore PK in PK-Sim®
  • Info: Molecule PBPK Models and the Toxophore Release
  • Compound: Naked Antibody
  • Compound: Toxophore
  • Configure the Simulation
  • Export the Simulation from PK-Sim to MoBi
  • Catch-Up Point 3
  • TMDD: Target-Mediated Drug Disposition QSP with MoBi®
  • Info: Target Mediated Drug Disposition (TMDD)
  • Module: TMDD Reactions
  • Observed Data: ADC Dose Escalation
  • Simulation: 0.3 mg/kg Dose (TMDD)
  • Simulation: ADC Dose Escalation (TMDD)
  • Catch-Up Point 4
  • Optional: Create TMDD from Scratch with MoBi®
  • Module: TMDD from Scratch
  • Reactions: Molecules
  • Reactions: Rates
  • Simulation: TMDD from Scratch
  • Catch-Up Point 5
  • The End
  • Final Overview
  • Brief Course Evaluation
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
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