Maternal-Fetal PBPK (M04-11)
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Info: Physiological Changes During Pregnancy
- Course Description
- Scientific Background
- Info: Physiological Changes During Pregnancy
- Info: Medication Use During Pregnancy is Increasin...
- Info: Change of Physiological Parameters
- Info: Fertilization Age impacts Organ Weight and B...
- Info: Typical Data Integration Workflow
- PBPK Model of a Non-Pregnant Woman in PK-Sim®
- Individual: Non-Pregnant Woman
- Expression Profile: Non-Pregnant Woman
- Compound: Metronidazole
- Administration Protocol: Metronidazole IV 500mg
- Catch-Up Point 1
- Simulation: Non-Pregnant Woman
- Export the Simulation from PK-Sim to MoBi®
- Catch-Up Point 2
- PBPK Model of a Pregnant Woman with MoBi®
- Info: Placenta Blood Circulation
- Info: Blood Flow in Fetus
- Info: Maternal Fetal PBPK Structure
- Spatial Structure and Transporter: Pregnancy
- Info: What Passive Transport Processes Define and ...
- Passive Transporter: Specific Renal Clearance
- Catch-Up Point 3
- Molecule Start Values Block: Update
- Simulation: Pregnant Woman
- Export Simulation
- Catch-Up Point 4
- Simulate a Pregnant Population
- Start PK-Sim
- Individual: Pregnant Woman
- Expression Profile: Pregnant Woman
- Population: Pregnant Population
- Adjust Pregnancy-Specific Parameters
- Simulation: Pregnant Population
- Observed Data: Add for Pregnant Simulation
- Catch-Up Point 5
- Simulate a Non-Pregnant Population
- Simulation: Non-Pregnant Woman
- Observed Data: For Non-Pregnant Simulation
- Population: Non-Pregnant Population
- Simulation: Non-Pregnant Population
- Run the simulation: Non-Pregnant Population
- Data for the Non-Pregnant Population Simulation
- Catch-Up Point 6
- Compare the Pregnant with the Non-Pregnant Populat...
- Compare Results
- Time Profile: Clearance
- Time Profile: Concentration
- Final Overview
- The End
- Brief Course Evaluation
- Course info
