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OSPS Version 11 → PBPK-QSP Modeling with MoBi®

Maternal-Fetal PBPK (M04-11)


Description
In this course, you will learn how to create a PBPK model of Metronidazole, an antibiotic against anerobic bacteria. You will create
• a non-pregnant individual
• a non-pregnant population
• a pregnant population, and
• a PBPK model of Metronidazole.
The exercises are based on the published PBPK model of Metronidazole:
• Dallmann et al. 2018, Clin Pharmacokinet. 57(6): 749-768.
Content
  • Course Description
  • Scientific Background
  • Info: Physiological Changes During Pregnancy sample
  • Info: Medication Use During Pregnancy is Increasing
  • Info: Change of Physiological Parameters
  • Info: Fertilization Age impacts Organ Weight and Bloodflow
  • Info: Typical Data Integration Workflow
  • PBPK Model of a Non-Pregnant Woman in PK-Sim®
  • Individual: Non-Pregnant Woman
  • Expression Profile: Non-Pregnant Woman
  • Compound: Metronidazole
  • Administration Protocol: Metronidazole IV 500mg
  • Catch-Up Point 1
  • Simulation: Non-Pregnant Woman
  • Export the Simulation from PK-Sim to MoBi®
  • Catch-Up Point 2
  • PBPK Model of a Pregnant Woman with MoBi®
  • Info: Placenta Blood Circulation
  • Info: Blood Flow in Fetus
  • Info: Maternal Fetal PBPK Structure
  • Spatial Structure and Transporter: Pregnancy
  • Info: What Passive Transport Processes Define and Not Define
  • Passive Transporter: Specific Renal Clearance
  • Catch-Up Point 3
  • Molecule Start Values Block: Update
  • Simulation: Pregnant Woman
  • Export Simulation
  • Catch-Up Point 4
  • Simulate a Pregnant Population
  • Start PK-Sim
  • Individual: Pregnant Woman
  • Expression Profile: Pregnant Woman
  • Population: Pregnant Population
  • Adjust Pregnancy-Specific Parameters
  • Simulation: Pregnant Population
  • Observed Data: Add for Pregnant Simulation
  • Catch-Up Point 5
  • Simulate a Non-Pregnant Population
  • Simulation: Non-Pregnant Woman
  • Observed Data: For Non-Pregnant Simulation
  • Population: Non-Pregnant Population
  • Simulation: Non-Pregnant Population
  • Run the simulation: Non-Pregnant Population
  • Data for the Non-Pregnant Population Simulation
  • Catch-Up Point 6
  • Compare the Pregnant with the Non-Pregnant Population
  • Compare Results
  • Time Profile: Clearance
  • Time Profile: Concentration
  • Final Overview
  • The End
  • Brief Course Evaluation
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
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