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OSPS Version 11 → PBPK-QSP Modeling with MoBi®

Lysosomal Trapping (M02-11)


Description
In this exercise, you will learn how to extend a PBPK model by new compartments and model the distribution of compounds based on partition coefficients. You will implement a simplified model of lysosomal trapping. Lysosomes are organelles within cells with low pH (4-5) that can bind basic lipophilic molecules.
Content
  • Introduction
  • Info: Lysosomal Trapping
  • Download the Midazolam PBPK Model
  • Building Blocks
  • Spatial Structure: Lysosome
  • Spatial Structure: pH, Volume, and Flow
  • Catch-Up Point 1
  • Spatial Structure & Molecules: Partition Coefficient
  • Spatial Structure: Add Lysosomes to All Relevant Organs
  • Catch-Up Point 2
  • Spatial Structure: Neighborhoods
  • Catch-Up Point 3
  • Passive Transports: Cell to Lysosome Diffusion
  • Molecules Start Values
  • Catch-Up Point 4
  • Simulation
  • Simulation
  • Final Overview
  • The End
  • Brief Course Evaluation
  • Info: Lysosomal Trapping (clone)
Completion rules
  • All units must be completed
  • Leads to a certificate with a duration: Forever
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